Materials Chemistry of Neural Interface Technologies and Recent Advances in Three-Dimensional Systems.
Yoonseok ParkTed S ChungGeumbee LeeJohn A RogersPublished in: Chemical reviews (2021)
Advances in materials chemistry and engineering serve as the basis for multifunctional neural interfaces that span length scales from individual neurons to neural networks, neural tissues, and complete neural systems. Such technologies exploit electrical, electrochemical, optical, and/or pharmacological modalities in sensing and neuromodulation for fundamental studies in neuroscience research, with additional potential to serve as routes for monitoring and treating neurodegenerative diseases and for rehabilitating patients. This review summarizes the essential role of chemistry in this field of research, with an emphasis on recently published results and developing trends. The focus is on enabling materials in diverse device constructs, including their latest utilization in 3D bioelectronic frameworks formed by 3D printing, self-folding, and mechanically guided assembly. A concluding section highlights key challenges and future directions.
Keyphrases
- neural network
- end stage renal disease
- drug discovery
- chronic kidney disease
- ejection fraction
- drug delivery
- peritoneal dialysis
- prognostic factors
- high resolution
- randomized controlled trial
- human health
- systematic review
- molecular dynamics simulations
- current status
- patient reported outcomes
- risk assessment
- label free
- climate change