Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro.
Diede W M BroekaartJ van ScheppingenJ J AninkL WiertsB van Het HofF E JansenW G SplietP C van RijenW W KamphuisH E de VriesE AronicaErwin Alexander van VlietPublished in: Neuropathology and applied neurobiology (2019)
This study provides evidence of dysregulation of the MMP/TIMP proteolytic system in TSC, which is associated with BBB dysfunction. As dysregulated MMP and TIMP expression can be ameliorated in vitro by miR146a and miR147b, these miRNAs deserve further investigation as a novel therapeutic approach.