Do patients with type 2 diabetes mellitus included in randomised clinical trials differ from general-practice patients? A cross-sectional comparative study.
Amandine DugardBruno GiraudeauClarisse Dibao-DinaPublished in: BMJ open (2024)
Patients with type 2 diabetes mellitus cared for in general practice differ in a number of important aspects from patients included in randomised controlled trials on which clinical practice guidelines are based. This situation hampers the applicability of these guidelines. Future randomised trials should include patients who better fit the 'average' general-practice patient with type 2 diabetes mellitus to help improve the translation of study findings in daily practice.
Keyphrases
- general practice
- clinical trial
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- primary care
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- physical activity
- open label
- cardiovascular disease
- patient reported outcomes
- study protocol
- type diabetes
- adipose tissue
- clinical practice
- glycemic control
- placebo controlled
- phase iii