Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities.
Kiep Minh DoShotaro HoshinoTakeshi KodamaHien Minh NguyenNaotaka IkumiHiroyasu OnakaHiroyuki MoritaPublished in: Journal of natural medicines (2024)
A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of five new pimarane diterpenes, kaempferiols E-I (1-5). The structures of 1-5 were elucidated by extensive spectroscopic techniques, including HR-ESI-MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1-3 were determined by the modified Mosher method, and those of 4 and 5 were established by ECD calculations. Further cytotoxic assay for all isolated compounds against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) indicated that 5 showed moderate cytotoxic activities against the three tested cell lines, with IC 50 values of 44.78, 25.97, and 41.39 Mμ for A549, HeLa, and MCF-7 cell lines, respectively.
Keyphrases
- ms ms
- breast cancer cells
- high resolution
- endothelial cells
- papillary thyroid
- mass spectrometry
- magnetic resonance
- molecular docking
- high throughput
- squamous cell
- molecular dynamics
- density functional theory
- cell cycle arrest
- molecular dynamics simulations
- squamous cell carcinoma
- induced pluripotent stem cells
- pluripotent stem cells
- cell death
- lymph node metastasis