Extracapsular nodal extension and tumor deposits in head and neck squamous cell carcinoma.

Leyre González-Vallejo Javier Blanco-Sainzdelamaza Arrate Querejeta-Ayerra Carlos-Miguel Chiesa-Estomba

Published in: Cancer reports (Hoboken, N.J.) (2023)

TDs in HNSCC are associated with a lower OS than ENE, despite intensified adjuvant therapy. Our results confirm a better prognosis for pN2a-ENE vs. pN3b-ENE, and pN3b-ENE vs. TDs. TDs may serve as an indicator of poor prognosis and require separate TNM classification in HNSCC staging. Larger studies are needed to evaluate TDs impact on treatment strategies and outcomes.

Keyphrases

poor prognosis
long non coding rna
lymph node
machine learning
deep learning
neoadjuvant chemotherapy
radiation therapy
metabolic syndrome