Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies.

Andreja VukasovicMaria Adelaide AsnaghiPetar KostesicHelen QuasnichkaCarmine CozzolinoMaja PusicLauren HailsNuala TrainorChristian KrauseElisa FigalloGiuseppe FilardoElizaveta KonAnke WixmertenDrazen MaticicGraziella PellegriniWael KafienahDamir HudetzTim SmithIvan MartinAlan IvkovicDavid Wendt

Published in: Cell proliferation (2019)

By demonstrating the safety and efficacy of bioreactor-generated grafts in two large animal models, this work represents a pivotal step towards implementing the bioreactor-based manufacturing system for the production of human cartilage grafts for clinical applications. Read the Editorial for this article on doi:10.1111/cpr.12625.

Keyphrases

wastewater treatment
endothelial cells
cardiac arrest
liver failure
extracellular matrix
drug induced
respiratory failure
pluripotent stem cells
single molecule
case control
quality improvement
intensive care unit
platelet rich plasma