Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes.
J Hernández-ValdezA Velázquez-ZepedaJ C Sánchez-MezaPublished in: PPAR research (2023)
Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the relationship between these compounds and one of the major nuclear receptor families controlling lipid and carbohydrate metabolism: the peroxisome proliferator-activated receptors (PPARs), PPAR α , PPAR β / δ , and PPAR γ ; this was possible through in silico , in vitro , and in vivo assays. The present review aims to show the effect of pesticides on PPARs and their contribution to the changes in energy metabolism that enable the development of obesity and type 2 diabetes mellitus.
Keyphrases
- insulin resistance
- type diabetes
- glycemic control
- metabolic syndrome
- weight loss
- risk assessment
- high fat diet induced
- weight gain
- adipose tissue
- gas chromatography
- skeletal muscle
- cardiovascular disease
- fatty acid
- body mass index
- high throughput
- mass spectrometry
- molecular docking
- physical activity
- high resolution
- tandem mass spectrometry
- liquid chromatography