Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study.
Xiong GaoWei LuoLiyuan QuMiaomiao YangSiyu ChenLi LeiShaohua YanHongbin LiangXinlu ZhangMin XiaoYulin LiaoAlex Pui-Wai LeeZhongjiang ZhouJiejian ChenQiuxia ZhangYuegang WangJiancheng XiuPublished in: European journal of preventive cardiology (2024)
This study provides causal evidence for the genetic association between lipid-lowering drugs and AA. Higher gene expression of HMGCR, PCSK9, and CETP increases AA risk. Furthermore, HMGCR inhibitors may link with smaller aortic lumen size.