Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study.

Xiong GaoWei LuoLiyuan QuMiaomiao YangSiyu ChenLi LeiShaohua YanHongbin LiangXinlu ZhangMin XiaoYulin LiaoAlex Pui-Wai LeeZhongjiang ZhouJiejian ChenQiuxia Zhang Yuegang Wang Jiancheng Xiu

Published in: European journal of preventive cardiology (2024)

This study provides causal evidence for the genetic association between lipid-lowering drugs and AA. Higher gene expression of HMGCR, PCSK9, and CETP increases AA risk. Furthermore, HMGCR inhibitors may link with smaller aortic lumen size.

Keyphrases

gene expression
aortic valve
dna methylation
left ventricular
genome wide
heart failure
fatty acid
copy number
pulmonary artery
aortic dissection