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Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study.

Xiong GaoWei LuoLiyuan QuMiaomiao YangSiyu ChenLi LeiShaohua YanHongbin LiangXinlu ZhangMin XiaoYulin LiaoAlex Pui-Wai LeeZhongjiang ZhouJiejian ChenQiuxia ZhangYuegang WangJiancheng Xiu
Published in: European journal of preventive cardiology (2024)
This study provides causal evidence for the genetic association between lipid-lowering drugs and AA. Higher gene expression of HMGCR, PCSK9, and CETP increases AA risk. Furthermore, HMGCR inhibitors may link with smaller aortic lumen size.
Keyphrases
  • gene expression
  • aortic valve
  • dna methylation
  • left ventricular
  • genome wide
  • heart failure
  • fatty acid
  • copy number
  • pulmonary artery
  • aortic dissection