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Convallatoxin, the primary cardiac glycoside in lily of the valley (Convallaria majalis), induces tissue factor expression in endothelial cells.

Mami MorimotoKohei TatsumiKatsuya YuuiIkuko TerazawaRisa KudoShogo Kasuda
Published in: Veterinary medicine and science (2021)
TF expression induced by CNT in endothelial cells can contribute to the development of a hypercoagulable state. The present study partially revealed the mechanisms underlying the CNT-induced hypercoagulable state. The findings can contribute to the development of a novel therapy for lily of the valley poisoning.
Keyphrases
  • endothelial cells
  • high glucose
  • poor prognosis
  • binding protein
  • single cell
  • long non coding rna
  • left ventricular
  • diabetic rats
  • vascular endothelial growth factor
  • drug induced
  • atrial fibrillation