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Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis.

Stephen Pj MacDonaldErika BosioGerben KeijzersSally BurrowsMoira HibbsHelen O'DonoghueDavid TaylorAshes MukherjeeFrances KinnearLisa SmartJuan-Carlos Ascencio-LaneEdward LittonJohn FraserNathan I ShapiroGlenn ArendtsDaniel Fatovichnull null
Published in: Intensive care medicine experimental (2023)
A consistent signal across a range of biomarkers of EG shedding or of endothelial activation or inflammation was not demonstrated. This could be explained by pre-existing EG shedding or overlap between the fluid volumes administered in the two groups in this clinical trial. Trial registration Australia New Zealand Clinical Trials Registry ACTRN126160000006448 Registered 12 January 2016.
Keyphrases
  • clinical trial
  • phase ii
  • oxidative stress
  • phase iii
  • study protocol
  • endothelial cells
  • septic shock
  • cardiac arrest
  • open label
  • double blind
  • intensive care unit
  • acute kidney injury
  • high dose
  • randomized controlled trial