Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells.

Yingzi ZhangJiao TianChi QuYang PengJinwei LeiKang LiBeige ZongLu SunShengchun Liu

Published in: Breast cancer (Tokyo, Japan) (2021)

SERPINA3 can regulate the migration, invasion and EMT of TNBC cells and increased expression of SERPINA3 confers resistance to cisplatin in TNBC cells. We discern it is required for the regulation of BC progression and is a critical target for the clinical treatment of BC.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
cell cycle arrest
breast cancer cells
cell migration
signaling pathway
poor prognosis
endoplasmic reticulum stress
cell death
cell proliferation
transcription factor
transforming growth factor
oxidative stress
long non coding rna