Evaluation of HPV and EBV in OSCC and the expression of p53, p16, E-cadherin, COX-2, MYC, and MLH1.
Marcos Antonio Pereira de LimaRoberta Barroso CavalcanteCláudio Gleidiston Lima da SilvaRenato Luiz Maia NogueiraGeamberg Einstein Cruz MacedoLara Eduardo de GalizaJuliana Viana PinheiroPedro Hugo Bezerra Maia FilhoSarah Ferreira SantosSilvia Helena Barem RabenhorstPublished in: Oral diseases (2021)
Our findings reinforce the hypothesis of the HPV-related oral carcinogenesis involving the expression of p16 and MYC, and MLH1 suppression. Exclusively cytoplasmic stainings for p16, MLH1, and MYC were also associated with more advanced tumors. Finally, in view of the lack of studies correlating the HPV or EBV infection to the expression of oncoproteins, more researches assessing a broader panel of markers and employing different approaches are still necessary in order to understand the role of these viruses as well as the molecular mechanisms involved in the development and progression of oral carcinomas.