Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity.

Federica BarbieriAdriana BajettoIrene DellacasagrandeAgnese SolariRoberto WurthVirginia FernandezSilvia RancatiDavide CeresaIrene AppolloniGiuseppa De LucaMariella DonoPaolo NozzaPiero SchiapparelliMonica GambaroPietro FiaschiGabriele GaggeroNiccolò CostanzoStefano ThellungPaolo MalatestaAldo PaganoGianluigi ZonaDavide De Pietri TonelliTullio Florio

Published in: Neuro-oncology (2023)

We report a role for CXCL11 and CXCL12 in the control of malignant features in stem-like cells isolated from human meningioma, providing a possible basis for the aggressive clinical behavior observed in subsets of these tumors. CXCR4/CXCR7 antagonists might represent a useful approach for meningioma at high risk of recurrence and malignant progression.

Keyphrases

endothelial cells
induced apoptosis
optic nerve
pluripotent stem cells
peripheral blood
cell cycle arrest
oxidative stress
genome wide
cell migration
gene expression
dna methylation