The fraction of CD117/c-KIT-expressing erythroid precursors predicts ESA response in low-risk myelodysplastic syndromes.

Anna RaimbaultRaphael ItzyksonLise WillemsAlice RousseauNicolas ChapuisStéphanie MathisSylvain ClauserIsabelle Radford-WeissDidier BouscaryMichaela FontenayOlivier KosmiderValérie Bardet

Published in: Cytometry. Part B, Clinical cytometry (2019)

The quantification of the CD117/c-KIT-expressing erythroid precursors could be proposed as a new theranostic and prognostic marker in MDS treated by ESA. Future studies will be required to determine whether modulating CD117/c-KIT expression and signaling could be used to improve anemia in MDS. © 2019 International Clinical Cytometry Society.

Keyphrases

nk cells
poor prognosis
chronic kidney disease
signaling pathway
current status
fluorescence imaging
iron deficiency
wild type