Evaluation of changes in biochemical composition of fetal brain between 18th and 40th gestational week in proton magnetic resonance spectroscopy.

Andrzej UrbanikMonika OstrogórskaJustyna KozubPaulina KarczIzabela Herman-Sucharska

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2018)

Changes in the 1H MRS spectrum are visible with increasing age of the fetus. All studied substances in fetal brain change their concentrations during pregnancy, which may be associated with the synaptic and dendritic development as well as myelination. Knowledge about the chemical changes in the fetal brain can provide valuable information in studies of the mechanisms of pregnancy and fetal development, define steps of brain metabolic development and explain reasons of pathologies.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
healthcare
pregnant women
weight gain
randomized controlled trial
multiple sclerosis
clinical trial
pregnancy outcomes
physical activity
preterm birth
body mass index
social media
study protocol
case control