Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin.

Jiafen QianWenjun ChenJianmei WuMeina LvShaojun JiangZhiwei ZengZongwei FangMingrong ChenJin-Hua Zhang

Published in: European journal of drug metabolism and pharmacokinetics (2022)

PNS can increase the blood concentration of warfarin, as well as the exposure time, and it can enhance the anticoagulant effect of warfarin by inhibiting the expression of the liver enzyme CYP3A4.

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
oral anticoagulants
poor prognosis
signaling pathway
binding protein