Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance.
Takeshi ShimizuTohru Miyoshi-AkiyamaKohei OguraShota MurataShota IshigeKiyohiro KaiKonosuke MitsutsukaHaruyoshi TomitaKoichi TanimotoAkio MatsumotoPublished in: Antimicrobial agents and chemotherapy (2020)
Sub-MICs of the 14-membered macrolides erythromycin (EM) and clarithromycin (CAM) decreased the growth of Pseudomonas aeruginosa PAO1 and increased its sensitivity to endogenous and exogenous nitrosative stress. However, a 16-membered macrolide, josamycin (JM), was not or less effective. In 9 of 13 non-multidrug-resistant P. aeruginosa (non-MDRP) and 9 of 27 MDRP ST235 strains, the sub-MIC of EM induced significant reductions in bacterial numbers following treatment with a nitric oxide donor.
Keyphrases
- pseudomonas aeruginosa
- multidrug resistant
- acinetobacter baumannii
- nitric oxide
- cystic fibrosis
- biofilm formation
- helicobacter pylori
- randomized controlled trial
- escherichia coli
- drug resistant
- high glucose
- stress induced
- systematic review
- gram negative
- diabetic rats
- hydrogen peroxide
- nitric oxide synthase
- staphylococcus aureus
- klebsiella pneumoniae
- combination therapy