Response of FcεRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria.

Mehran Alizadeh Aghdam Edward F KnolMignon van den ElzenConstance den Hartog JagerHarmieke van Os-MedendorpAndré C KnulstHenny G OttenHeike Röckmann

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

FcεRI expression on basophils decreased rapidly, while anti-IgE-induced degranulation significantly increased due to omalizumab treatment in patients with CSU, persisting at least for 3 months after stopping the treatment. None of the markers were able to predict the effectiveness of treatment. Whether basophils play a role in omalizumab responsiveness in CSU remains unclear.

Keyphrases

systematic review
poor prognosis
oxidative stress
drug induced
high glucose
smoking cessation