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The Win Ratio Method in Heart Failure Trials: Lessons Learnt From Empulse.

Stuart J PocockJoão Pedro FerreiraTimothy J CollierChristiane E AngermannJan BiegusSean P CollinsMikhail KosiborodMichael E NassifPiotr PonikowskiMitchell A PsotkaJohn R TeerlinkJasper TrompJohn GregsonJonathan P BlatchfordCordula ZellerAdriaan A Voors
Published in: European journal of heart failure (2023)
The EMPULSE trial findings illustrate how deaths, clinical events and patient-reported outcomes can be integrated into a win ratio analysis strategy that yields clinically meaningful findings of patient benefit. This has implications for future trial designs that recognize the clinical priorities of patient evaluation and the need for efficient progress towards approval of new treatments. This article is protected by copyright. All rights reserved.
Keyphrases
  • patient reported outcomes
  • heart failure
  • case report
  • phase iii
  • study protocol
  • left ventricular
  • phase ii
  • randomized controlled trial
  • atrial fibrillation
  • double blind