Mutations of BRCA1 , BRCA2 , and PALB2 Genes in Breast Tumor Tissue: Relationship with the Effectiveness of Neoadjuvant Chemotherapy and Disease Prognosis.

Matvey M TsyganovSofia S SorokovikovaElizaveta A LutzkayaMarina K Ibragimova

Published in: Genes (2023)

Currently, there is little data on the effect of chromosomal aberrations and mutations in the BRCA1/2 and PALB2 genes on the effectiveness of treatment and prognosis of the disease. At the same time, the study of these genes has great potential for testing focused on a personalized approach to the treatment of patients with breast cancer.

Keyphrases

neoadjuvant chemotherapy
genome wide
randomized controlled trial
systematic review
lymph node
copy number
locally advanced
bioinformatics analysis
dna methylation
sentinel lymph node
risk assessment
replacement therapy
data analysis
smoking cessation