Randomised, cOntrolled Multicentre trial of 26 weeks subcutaneous liraglutide (a glucagon-like peptide-1 receptor Agonist), with or without contiNuous positive airway pressure (CPAP), in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnoEa (OSA) (ROMANCE): study protocol assessing the effects of weight loss on the apnea-hypnoea index (AHI).
Victoria S SprungGraham J KempJohn Ph WildingValerie AdamsKieran MurphyMalcolm BurgessStephen EmegboMatthew ThomasAlexander J NeedhamAndrew WeimkenRichard J SchwabAri ManuelSonya E CraigDaniel J CuthbertsonPublished in: BMJ open (2020)
ISRCTN16250774. EUDRACT No. 2014-000988-41. UTN U1111-1139-0677.
Keyphrases
- positive airway pressure
- study protocol
- obstructive sleep apnea
- weight loss
- randomized controlled trial
- sleep apnea
- bariatric surgery
- clinical trial
- glycemic control
- roux en y gastric bypass
- open label
- gastric bypass
- sleep quality
- physical activity
- gestational age
- placebo controlled
- type diabetes
- body mass index
- weight gain
- phase ii
- depressive symptoms
- skeletal muscle
- adipose tissue