The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells.

Deborah SchneiderRobert Lorenz ChuaNicole MolitorFeda H HamdanEva Maria RettenmeierEvangelos ProkakisVivek Kumar MishraVijayalakshmi KariFlorian WegwitzSteven A JohnsenRobyn Laura Kosinsky

Published in: Clinical epigenetics (2019)

Our findings reveal that RNF40 is essential for maintaining tumorigenic features of CRC cells in vitro by controlling the expression of genes encoding central apoptotic regulators.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
genome wide
pi k akt
signaling pathway
poor prognosis
oxidative stress
dna damage response
transcription factor
single cell
anti inflammatory
cell proliferation
bioinformatics analysis
gene expression