Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics.
Haohan ZhouJiayi TianHongyu SunJiaying FuNan LinDanni YuanLi ZhouMeihui XiaLiankun SunPublished in: International journal of nanomedicine (2022)
Our research suggests that treatment of bare MNPs in HeLa and SiHa cells induced significant expression changes in PTK2B, PPFIA4, SMAD7, and IL1B, which play crucial roles in cervical cancer development and progression. Interactions of the key genes with specific anti-cancer drugs must be considered in the rational design of MNP drug delivery systems.
Keyphrases
- iron oxide nanoparticles
- cell cycle arrest
- induced apoptosis
- bioinformatics analysis
- poor prognosis
- high glucose
- epithelial mesenchymal transition
- drug induced
- cell death
- diabetic rats
- transforming growth factor
- genome wide
- copy number
- endoplasmic reticulum stress
- cell proliferation
- long non coding rna
- transcription factor
- combination therapy