Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers.

João Soeiro Teodoro Ana Teresa VarelaFilipe Valente DuarteAna Patrícia GomesCarlos Marques PalmeiraAnabela Pinto Rolo

Published in: European journal of clinical investigation (2018)

Pretreatment with Ind or NAD+ protects fatty livers by maintaining mitochondrial calcium homoeostasis, thus, preserving mitochondrial function and energetic balance. As such, CypD might be a new protective target against I/RI in fatty livers.

Keyphrases

oxidative stress
fatty acid
acute myocardial infarction
cerebral ischemia
acute coronary syndrome
atrial fibrillation
coronary artery disease