In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans.
Rungnapa BoonpawaAlbertus SpenkelinkAns PuntIvonne M C M RietjensPublished in: British journal of pharmacology (2017)
The present study shows how plasma concentrations of genistein and its metabolites and oestrogenic dose levels of genistein in humans can be predicted by combining in vitro oestrogenicity with PBK model-based reverse dosimetry, eliminating the need for human intervention studies.