Phase 1 Study of MK-5475, an Inhaled Soluble Guanylate Cyclase Stimulator, in Participants with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease.
Ednan K BajwaDawn CislakAmit KumarDan LiEric J MessinaTom ReyndersJean-François DenefVasile CorceaKetan P BuchEseng LaiS Aubrey StochPublished in: International journal of chronic obstructive pulmonary disease (2024)
The favorable safety profile and numerical reductions in PVR observed support further clinical development of inhaled MK-5475 for PH-COPD treatment.