P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
Sergio Rodriguez-CuencaStefania CarobbioGwendolyn Barceló-CoblijnXavier PrieurJoana RelatRamon AmatMark CampbellAna Rita DiasMyriam BahriSarah L GrayAntonio Vidal-PuigPublished in: Diabetes, obesity & metabolism (2018)
Our data demonstrate that P465L confers partial resistance to the hypolipidemic action of fibrates. These results show that the fatty liver phenotype observed in P465L mutant mice is not only the consequence of dysfunctional adipose tissue, but also involves defective liver metabolism. All in all, the deleterious effects of P465L-PPARγ mutation may be magnified by their collateral negative effect on PPARα function.