Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.
Kolja PochaAndreas MockCarmen RappSteffen DettlingRolf WartaChristoph GeisenbergerChristine JungkLeila R MartinsNiels GrabeDavid ReussJuergen DebusAndreas von DeimlingAmir AbdollahiAndreas UnterbergChristel C Herold-MendePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
The expression of surfactant metabolism-related genes (SFTPA1, SFTPB, and NAPSA) defines an inflamed subtype of lung adenocarcinoma brain metastases characterized by high abundance of TILs in close vicinity to tumor cells, a prolonged survival, and a tumor microenvironment which might be more accessible to immunotherapeutic approaches.