Gentiopicroside Ameliorated Ductular Reaction and Inflammatory Response in DDC-induced Murine Cholangiopathies Model.
Juan HaoJian WuQuan-Jun YangKan LuYi XuYiyue ChenJibo LiuXiaohong ShaoChunling ZhuYaqin DingXin XiePublished in: Current molecular pharmacology (2023)
GPS alleviated chronic DDC diet-induced cholangiopathy disorder by improving the ductular reaction, periductal fibrosis, oxidative stress and inflammatory response. Its dosage-dependent pharmacological effects indicated that GPS warrants its further evaluation in clinical trials for cholangiopathy.
Keyphrases
- inflammatory response
- diabetic rats
- oxidative stress
- clinical trial
- lipopolysaccharide induced
- lps induced
- toll like receptor
- high glucose
- drug induced
- dna damage
- electron transfer
- induced apoptosis
- randomized controlled trial
- endothelial cells
- double blind
- signaling pathway
- endoplasmic reticulum stress
- placebo controlled