Protective Effects of Anethum graveolens Seed's Oil Nanoemulsion Against Cadmium-Induced Oxidative Stress in Mice.
Negin ShafaeiSeyed Mohammad Adel BarkhordarFatemeh RahmaniSajed NabiReza Baratpour IdlikiMasoumeh AlimirzaeiEhsan KarimiEhsan OskoueianPublished in: Biological trace element research (2020)
The cadmium (Cd) is a toxic heavy metal that induces oxidative stress in both humans and animals. The plant phenolic compounds are capable of alleviating the toxicity of heavy metals. The encapsulation of plant bioactive compounds using nanoemulsion technology could enhance their bioefficacy. In this study, the protective effects of Anethum graveolens seed's oil nanoemulsion (AGN) against cadmium-induced oxidative stress in mice were studied. The results showed that the major bioactive compounds of essential oil were carvone and limonene. The result of particle size analysis revealed the pseudo-spherical droplets with nanometer size (148.8 ± 9.48 nm), homogenous dispersion, and physical colloidal stability. The Cd intoxication in mice (5 mg/kg BW for 30 days) reduced the body weight gain; however, treatment of the mice with different concentration of AGN (0.125, 0.25, and 0.5 mg/L, 30 days) through drinking water improved the body weight loss, liver Cd deposition, lipid peroxidation, cellular antioxidant redox potential, and inflammation in the liver, kidney, and brain of the mice challenged by cadmium-induced oxidative stress. The results of the present study revealed that drinking the essential oil of Anethum graveolens nanoemulsion containing carvone and limonene could be a promising strategy to protect the tissues against cadmium-induced oxidative damage.
Keyphrases
- heavy metals
- oxidative stress
- essential oil
- drinking water
- high fat diet induced
- health risk assessment
- health risk
- weight gain
- weight loss
- risk assessment
- hydrogen peroxide
- body mass index
- gene expression
- diabetic rats
- physical activity
- single cell
- fatty acid
- dna damage
- birth weight
- insulin resistance
- wild type
- nk cells
- metabolic syndrome
- white matter
- climate change
- sewage sludge
- resting state
- glycemic control
- subarachnoid hemorrhage
- cell wall