Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells.
Alexander N ChernovAlexandr V KimSofia S SkliarEvgeniy V FedorovAnna N TsapievaTatiana A FilatenkovaAleksei L ChutkoMarina V MatskoElvira S GalimovaOlga V ShamovaPublished in: Cancer chemotherapy and pharmacology (2024)
The combination of antimicrobial peptides and chemical drugs enhances the cytotoxicity of chemotherapy and exerts synergistic antitumor effects in primary GBM cells. Moreover, in vivo study provided the first evidence that LL-37 could effectively inhibit brain tumor growth in rat C6 intracerebral GBM model. These results suggested a significant strategy for proposing a promising therapy for the treatment of GBM.
Keyphrases
- induced apoptosis
- cell cycle arrest
- poor prognosis
- oxidative stress
- locally advanced
- endoplasmic reticulum stress
- signaling pathway
- cell death
- squamous cell carcinoma
- white matter
- resting state
- cell proliferation
- brain injury
- binding protein
- long non coding rna
- single molecule
- combination therapy
- drug induced
- cerebral ischemia
- chemotherapy induced
- replacement therapy
- smoking cessation