Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.
Qian DuMeiying ZhangAiai GaoTao HeMingzhou GuoPublished in: Cancer biology & therapy (2024)
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 ( ZSCAN23 ) is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In this study, we explored the epigenetic regulation and the function of ZSCAN23 in PDAC. ZSCAN23 was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of ZSCAN23 inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. ZSCAN23 suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, ZSCAN23 inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. ZSCAN23 is frequently methylated in PDAC and may serve as a detective marker. ZSCAN23 suppresses PDAC cell growth both in vitro and in vivo .
Keyphrases
- poor prognosis
- induced apoptosis
- binding protein
- signaling pathway
- cell proliferation
- dna methylation
- computed tomography
- endoplasmic reticulum stress
- gene expression
- oxidative stress
- stem cells
- magnetic resonance imaging
- type diabetes
- transcription factor
- single cell
- cell therapy
- magnetic resonance
- mesenchymal stem cells
- amino acid
- small molecule
- bone marrow