Identification of Ten Mitosis Genes Associated with Tamoxifen Resistance in Breast Cancer.
Xi SunShuning DingShuangshuang LuZheng WangXiaosong ChenKunwei ShenPublished in: OncoTargets and therapy (2021)
Our study suggested mitosis-related genes are mainly involved in tamoxifen resistance, and high expression of these genes could predict poor prognosis of patients receiving tamoxifen. These genes may be potential targets to improve efficacy of endocrine therapy in breast cancer, and inhibitors targeted these genes could be used in endocrine-resistant patients.
Keyphrases
- poor prognosis
- bioinformatics analysis
- long non coding rna
- genome wide
- breast cancer cells
- estrogen receptor
- positive breast cancer
- genome wide identification
- ejection fraction
- newly diagnosed
- genome wide analysis
- prognostic factors
- cancer therapy
- risk assessment
- bone marrow
- gene expression
- drug delivery
- climate change
- transcription factor
- smoking cessation