Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases.
Mohit M HulsurkarSatadru K LahiriJason KarchMeng C WangXander H T WehrensPublished in: Expert opinion on therapeutic targets (2022)
Enhanced SR calcium release via RyR2 and reduced SR reuptake via SERCA2a, increased VDAC and MCUC-mediated calcium uptake into mitochondria, and enhanced lysosomal calcium-release via lysosomal TPC and TRPML may all contribute to aberrant calcium homeostasis causing heart disease. While mechanisms of this crosstalk need to be studied further, interventions targeting these calcium channels or combinations thereof might represent a promising therapeutic strategy.