Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort.

Kelly G KnuppErin LeisterJason CoryellKatherine C NickelsNicole RyanElizabeth Juarez-ColungaWilliam D GaillardJohn R MytingerAnne T BergJohn J MillichapDouglas R NordliSucheta JoshiRenée A ShellhaasTobias LoddenkemperDennis DlugosElaine WirrellJoseph SullivanAdam L HartmanEric H KossoffZachary M GrinspanLorie Hamikawanull null

Published in: Epilepsia (2016)

Greater than one third of children with IS will respond to a second medication. Choosing a standard medication (ACTH, oral corticosteroids, or vigabatrin) that has a different mechanism of action appears to be more effective. Rapid initial treatment increases the likelihood of response to the second treatment.

Keyphrases

healthcare
clinical trial
emergency department
cross sectional
replacement therapy