An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.
Ting Yat WongJoaquim RaduaEdith Pomarol-ClotetRaymond SalvadorAnton Albajes-EizagirreAleix SolanesErick J Canales-RodriguezAmalia Guerrero-PedrazaSalvador SarroTilo KircherIgor NenadicAxel KrugDominik GrotegerdUdo DannlowskiStefan BorgwardtAnita Riecher-RösslerAndre SchmidtChristina AndreouChristian G HuberJessica TurnerVince CalhounWenhao JiangSarah ClarkEsther WaltonGianfranco SpallettaNerisa BanajFabrizio PirasValentina CiulloDaniela VecchioIrina LebedevaAlexander S TomyshevVasily KaledaTatyana KlushnikGeraldo Busatto FilhoMarcus Vinicius ZanettiMauricio Henriques SerpaPedro Gomes Penteado RosaRyota HashimotoMasaki FukunagaAnja RichterBernd KrämerOliver GruberAristotle N VoineskosErin W DickieDavid TomecekAntonin SkochFilip SpanielCyril HoschlAlessandro BertolinoAurora BonvinoAnnabella Di GiorgioLaurena HolleranSimone CiufoliniTiago Reis MarquesPaola DazzanRobin MurrayJelle LamsmaWiepke CahnNeeltje van HarenAna M Díaz-ZuluagaJulián A Pineda-ZapataCristian VargasCarlos López-JaramilloTheo G M van ErpRuben C GurThomas Nickl-JockschatPublished in: Psychological medicine (2019)
These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.