Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients.
Hyun Suk ChoiKyong Hoon KimSeohoon JinJinhyun KimInseol YooSeung Pil PackUn-Hwan HaTae Won ParkSoo An ChoiSoon Hong YukSeong Wook KangYong Woo JungPublished in: Immune network (2018)
Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes and developing immune disorders including autoimmunity. In the synovium of rheumatoid arthritis (RA) patients, increased expression of S1P was reported, and the interaction between S1P and S1P receptor 1 (S1P1) has been suggested to regulate the expression of inflammatory genes and the proliferation of synovial cells. In this study, we investigated the level of S1P1 mRNA expression in the blood leukocytes of RA patients. In contrast to the previous reports, the expression level of this gene was not correlated to their clinical scores, disease durations and ages. However, S1P1 was transcribed at a significantly lower level in the circulating leukocytes of RA patients when compared to age-, and sex-matched healthy controls. Since these data may suggest the participation of S1P1, further studies are needed to determine the role of this receptor in the pathogenesis of RA.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- poor prognosis
- ejection fraction
- chronic kidney disease
- disease activity
- peritoneal dialysis
- binding protein
- prognostic factors
- gene expression
- peripheral blood
- oxidative stress
- magnetic resonance imaging
- interstitial lung disease
- emergency department
- genome wide
- systemic sclerosis
- cell death
- induced apoptosis
- mass spectrometry
- electronic health record
- transcription factor
- copy number
- endoplasmic reticulum stress
- bioinformatics analysis