Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes.

Hengliang ZhangPayel SenJules HamersTheresa SittigBrent WoestenburgAllessandra MorettiAndreas DendorferDaphne Merkus

Published in: Stem cell research & therapy (2024)

By interfering with the differentiation process of hiPSC with a specific concentration of RA at a specific time, we were able to successfully induce CMs and EHTs with a phenotype similar to that of the left ventricle or right ventricle.

Keyphrases

pulmonary artery
pulmonary hypertension
mitral valve
high glucose
endothelial cells
congenital heart disease
coronary artery
diabetic rats
heart failure
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
systemic lupus erythematosus
disease activity
left ventricular
atrial fibrillation