The pan-tumor landscape of targetable kinase fusions in circulating tumor DNA.

Jessica K LeeMehlika Hazar-RethinamBrennan DeckerOle GjoerupRussell W Madison Daniel S Lieber Jon H ChungAlexa B SchrockJames CreedenJeffrey M VenstromBrian M AlexanderGeoffrey R Oxnard

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Targetable kinase fusions are identified in ctDNA across cancer types. In pairs with tissue-identified fusions, fusion detection in ctDNA is reliable with elevated ctDNA fraction. These data support the validity of CGP to enable ctDNA-based fusion detection for informing clinical care in advanced cancer.

Keyphrases

circulating tumor
advanced cancer
palliative care
cell free
circulating tumor cells
loop mediated isothermal amplification
healthcare
protein kinase
papillary thyroid
label free
tyrosine kinase
big data
electronic health record
pain management
squamous cell
machine learning
squamous cell carcinoma
childhood cancer