Incomplete capture of apremilast in Clinical Practice Research Datalink Aurum: An example of exposure misclassification of specialty treatments in United Kingdom general practice databases.
Rebecca PerssonSusan S JickPublished in: Pharmacoepidemiology and drug safety (2023)
CPRD Aurum captures only one apremilast prescription for most recorded users, though questionnaire responses indicated most patients received multiple prescriptions. Researchers using any UK GP database should be aware of potential for significant exposure misclassification of apremilast and other treatments classified as specialist or shared care by local Area Prescribing Committees.
Keyphrases
- general practice
- clinical practice
- end stage renal disease
- palliative care
- primary care
- ejection fraction
- cross sectional
- healthcare
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- adverse drug
- patient reported
- risk assessment
- machine learning
- patient reported outcomes
- big data
- health insurance
- psychometric properties
- electronic health record