Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease.

Ilaria LaudadioClaudia CarissimiNoemi ScafaAlex BastianelliValerio FulciAlessandra RenziniGiusy RussoSalvatore OlivaRoberta VitaliFrancesca PaloneSalvatore CucchiaraLaura Stronati

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)

This study demonstrates that intestinal PDOs may develop an inflammatory-derived fibrosis thus representing a promising tool to study fibrogenesis in IBD. Fibrotic PDOs show increased expression of EMT genes. In particular, fibrotic CD-PDOs display a specific gene expression signature compared to UC and CTRL-PDOs.

Keyphrases

gene expression
systemic sclerosis
poor prognosis
dna methylation
transcription factor
liver fibrosis
ulcerative colitis