A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.

Danuta R GawelJordi Serra-MusachSandra LiljaJesper AagesenAlex ArenasBengt AskingMalin BengnérJanne BjörkanderSophie BiggsJan ErnerudhHenrik HjortswangJan-Erik KarlssonMattias KöpsenEun Jung LeeAntonio LentiniXinxiu LiMattias MagnussonDavid Martínez-EnguitaAndreas MatussekColm E NestorSamuel SchäferOliver SeifertCeylan SonmezHenrik StjernmanAndreas TjärnbergSimon WuKarin ÅkessonAlex K ShalekMargaretha StenmarkerHuan ZhangMika GustafssonMikael Benson

Published in: Genome medicine (2019)

Overall, our results support that our strategy has the potential to help prioritize diagnostic and therapeutic targets in human disease.

Keyphrases

single cell
endothelial cells
rna seq
induced pluripotent stem cells
pluripotent stem cells
risk assessment
climate change