Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage.
Ana C de BragançaRegina L M MoreauThales de BritoMaria H M ShimizuDaniele CanaleDenise A de JesusAna M G SilvaPedro H GoisAntonio C SeguroAntônio José MagaldiPublished in: PloS one (2017)
Results showed that Ec induced an increase in AQP2 expression, evidencing another mechanism that might contribute to cause rapid hyponatremia. In addition, they showed that NAC and Allo protected against OS, but only Allo decreased rhabdomyolysis and hyperthermia.
Keyphrases
- oxidative stress
- diabetic rats
- acute kidney injury
- reactive oxygen species
- poor prognosis
- high glucose
- transcription factor
- skeletal muscle
- ischemia reperfusion injury
- induced apoptosis
- drug induced
- long non coding rna
- loop mediated isothermal amplification
- binding protein
- heat shock
- atrial fibrillation
- endoplasmic reticulum stress
- signaling pathway
- stress induced
- genome wide analysis