Login / Signup

Differential cortical layer engagement during seizure initiation and spread in humans.

Pierre BourdillonLiankun RenMila HalgrenAngelique C PaulkPariya SalamiIstván UlbertDaniel FaboJean-Remi KingKane M SjobergEmad N EskandarJoseph R MadsenEric HalgrenSyndey S Cash
Published in: Nature communications (2024)
Despite decades of research, we still do not understand how spontaneous human seizures start and spread - especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-electrodes to simultaneously record the local field potentials and multi-unit neural activities across the six layers of the neocortex during focal seizures in humans. We found that, within the ictal onset zone, the discharges generated during a seizure consisted of current sinks and sources only within the infra-granular and granular layers. Outside of the seizure onset zone, ictal discharges reflected current flow in the supra-granular layers. Interestingly, these patterns of current flow evolved during the course of the seizure - especially outside the seizure onset zone where superficial sinks and sources extended into the deeper layers. Based on these observations, a framework describing cortical-cortical dynamics of seizures is proposed with implications for seizure localization, surgical targeting, and neuromodulation techniques to block the generation and propagation of seizures.
Keyphrases
  • temporal lobe epilepsy
  • endothelial cells
  • drinking water
  • solar cells
  • social media
  • cancer therapy
  • pluripotent stem cells