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Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.

Lena ChngDeborah C HoltMatthew A FieldJoshua Reginald FrancisDev TillakaratneMilou H DekkersGreg RobinsonKate E MounseyRebecca PavlosAsha C BowenKatja FischerAnthony T PapenfussRobin B GasserPasi K KorhonenBart J CurrieJames S McCarthyCielo Pasay
Published in: PLoS neglected tropical diseases (2021)
This newly developed qPCR assay, combined with the use of an alternative non-invasive swab sampling technique offers the possibility of enhanced diagnosis of scabies. Further studies will be required to better define the diagnostic performance of these tests.
Keyphrases
  • copy number
  • mitochondrial dna
  • genome wide
  • high throughput
  • dna methylation
  • high frequency
  • quantum dots
  • cancer therapy