Early Clinically Important Improvement (ECII) and Exacerbation Outcomes in COPD Patients.
Konstantinos KostikasAlexander J MackayClaus F VogelmeierStefan-Marian FrentPritam GuptaDonald BanerjiFrancesco PatalanoPascal J PfisterJadwiga A WedzichaPublished in: International journal of chronic obstructive pulmonary disease (2020)
ECII is a novel composite endpoint, based on clinically relevant improvement in lung function and PROs in the early phase of treatment intervention that may predict subsequent exacerbation risk and may be used in clinical trials.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- clinical trial
- end stage renal disease
- cystic fibrosis
- air pollution
- randomized controlled trial
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute respiratory distress syndrome
- intensive care unit
- patient reported
- glycemic control
- phase ii
- double blind