Spectral homogeneity of human platelets investigated by SERS.
Andrey ZyubinVladimir RafalskiyMikhail LopatinElizaveta DemishkevichEkaterina MoiseevaKarina MatveevaIgor KonArtemii KhankaevAnna KundalevichViktoria ButovaLeonard LipnevichIvan LyatunIlia SamusevValery BryukhanovPublished in: PloS one (2022)
This paper describes a detailed study of the spectral homogeneity of human platelets using Surface-enhanced Raman spectroscopy (SERS). We used a combined approach based on multivariate methods as principal component analysis and pair correlation algorithms to investigate platelets spectral properties. The correlation coefficients for each sample have been calculated, and the average coefficient of determination has been estimated. The high degree of spectral homogeneity inside one probe and between them has been revealed. The prospects of obtained results usage for pathologies based on platelet conformations during cardiovascular diseases have been demonstrated.
Keyphrases
- raman spectroscopy
- optical coherence tomography
- endothelial cells
- resting state
- gold nanoparticles
- cardiovascular disease
- dual energy
- induced pluripotent stem cells
- machine learning
- pluripotent stem cells
- sensitive detection
- magnetic resonance imaging
- type diabetes
- single cell
- magnetic resonance
- coronary artery disease
- cardiovascular events
- atomic force microscopy
- diffusion weighted imaging
- cardiovascular risk factors