L-asparaginase isolated from Streptomyces ansochromogenes promotes Th1 profile and activates CD8+ T cells in human PBMC: an in vitro investigation.
G R da Silva LacerdaC M L de MeloA K de Araújo SoaresL R MoreiraM C CoriolanoG M de Souza LimaT H NapoleãoVirginia Maria Barros de LorenaL A de Oliveira da SilvaS C do NascimentoPublished in: Journal of applied microbiology (2018)
L-asparaginase is an indispensable component of the chemotherapeutic treatment of acute lymphoblast leukaemia (ALL) and acute myeloid leukaemia (AML). Currently, drugs such as Asparaginase® , Kidrolase® , and Elspar® and Erwinase® are efficient against leukemic disease, but promote immunosuppression and other side effects in human organisms. Our purified S. ansochromogenes L-asparaginase showed promissory results inducing, in vitro, higher immunostimulation in human PBMC, especially in T CD8+ lymphocyte subsets.