Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition.

Senna Staessens Mouhamed Djahoum Moussa Adeline Pierache Antoine Rauch Natacha Rousse Eric Boulleaux Alexandre Ung Linda Desender Bénédicte Pradines André Vincentelli Olaf Mercier Julien Labreuche Alain Duhamel Eric Van Belle Flavien Vincent Annabelle Dupont Karen Vanhoorelbeke Delphine Corseaux Simon F De Meyer Sophie Susen

Published in: Journal of thrombosis and haemostasis : JTH (2022)

We found that thrombus composition is heterogenous, independent of their location, consisting of two types: RBC-rich and a fibrin-rich types. We also found that NETs play a minor role. These findings are important to improve current anticoagulation strategies in ECMO.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
respiratory failure
atrial fibrillation
venous thromboembolism