Systematic Review of Available CAR-T Cell Trials around the World.
Luciana Rodrigues Carvalho BarrosSamuel Campanelli Freitas CoutoDaniela da Silva SanturioEmanuelle Arantes PaixãoFernanda CardosoViviane Jennifer da SilvaPaulo KlingerPaula do Amaral Costa RibeiroFelipe Augusto RósThéo Gremen Mimary OliveiraEduardo Magalhães RegoRodrigo Nalio RamosVanderson Geraldo RochaPublished in: Cancers (2022)
In this systematic review, we foresee what could be the approved scenario in the next few years for CAR-T cell therapies directed against hematological and solid tumor malignancies. China and the USA are the leading regions in numbers of clinical studies involving CAR-T. Hematological antigens CD19 and BCMA are the most targeted, followed by mesothelin, GPC3, CEA, MUC1, HER2, and EGFR for solid tumors. Most CAR constructs are second-generation, although third and fourth generations are being largely explored. Moreover, the benefit of combining CAR-T treatment with immune checkpoint inhibitors and other drugs is also being assessed. Data regarding product formulation and administration, such as cell phenotype, transfection technique, and cell dosage, are scarce and could not be retrieved. Better tracking of trials' status and results on the ClinicalTrials.gov database should aid in a more concise and general view of the ongoing clinical trials involving CAR-T cell therapy.
Keyphrases
- cell therapy
- systematic review
- single cell
- clinical trial
- meta analyses
- stem cells
- small cell lung cancer
- mesenchymal stem cells
- randomized controlled trial
- drug delivery
- emergency department
- machine learning
- tyrosine kinase
- electronic health record
- epidermal growth factor receptor
- dendritic cells
- open label
- combination therapy